Год выпуска: 2013 Автор: Tania Shakoori and Abdul Rauf Shakoori Издательство: LAP Lambert Academic Publishing Страниц: 116 ISBN: 9783659341588
Описание
The study describes the link between serum levels of surfactant protein D, its genetic polymorphisms and risk of Chronic Obstructive Pulmonary Disease. Single nucleotide polymorphisms has been genotyped using PCR and restriction analysis. Serum SP-D levels were measured using a specific immunoassay. Autoantibodies including anti dsDNA, antinuclear and antinucleosome antibodies levels were also recorded. It was found that allele ‘A’ at rs3088308 (p=0.000, B=-0.399) and ‘C’ allele at rs721917 (p=0.021; B=-0.344) were associated with significantly low serum SP-D levels. Additionally allele ‘T’ at rs721917 was significantly associated with risk of COPD (p=0.042). Haplotype ‘A C’ (A in rs3088308 and C in rs721917) was under-represented in cases as compared to controls (p=0.005). The results showed that exacerbation status is a significant determinant of serum SP-D even after adjusting for genetic factors. This study reports for the first time that rs3088308 is an important factor...
