Год выпуска: 2012 Автор: Ripudaman Singh,Kanchan Vohra and Harpreet Singh Kalra Издательство: LAP Lambert Academic Publishing Страниц: 108 ISBN: 9783659256875
Описание
Osteoarthritis (OA) is defined as a focal lesion of the articular cartilage, combined with a hypertrophic reaction (sclerosis) in the subchondral bone and new bone formation (osteophytes) at the joint margins (Van den Berg, 2000). OA is associated with a loss of balance between synthesis and degradation of macromolecules needed to provide articular cartilage with its biomechanical and functional properties. At the same time, changes occur in the structure and metabolism of synovium, subchondral bone and other tissues of joint. Conventional therapeutic options employed in the management of osteoarthritis are simple analgesics & NSAIDs, but these options produce sub-optimal benefits and are associated with adverse-safety profile (Walker- Bone, 2003). NSAIDs, in particular can cause serious side effects including peptic –ulcer and hepatic or renal failure (Sanghi et al., 2009). Other available therapies like nutraceuticals (e.g. glucosamine, chondriotin sulfate etc.) and various...
