Год выпуска: 2012 Автор: Prasanth Kumar,Saumya Patel and Himanshu Pandya Издательство: LAP Lambert Academic Publishing Страниц: 104 ISBN: 9783659153129
Описание
Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporters known to confer multidrug resistance (MDR) to a number of important anticancer agent and play an important function in governing drug absorption. This book deals about the development of homology model of BCRP and its correspondence with experimentally known topology. This study also helped to understand the protein dynamics of BCRP through coarse-grained normal mode analysis. Structural analysis of substrate specificity bestowed by specific amino acids and its interaction with various synthetic and natural compounds provided clues of developing an efficient inhibitor.
Мария! Спасибо огромное за проделанную работу, я ее внимательно изучала, чтобы достойно представить :)). Надо будет держаться ОЧЕНЬ уверено :)), работа после вашего сопровождения получилась замечательная :)), еще раз и снова Вам огромное, огромное спасибо!!!