Multi-drug Resistance Gene Polymorphisms in Malay Leukemic Patients Год выпуска: 2011Автор: Badrul Hisham Yahaya,Rosline Hassan and Narazah YusoffИздательство: LAP Lambert Academic PublishingСтраниц: 192ISBN: 9783843392846Описание The most frequent single nucleotide polymorphisms (SNPs) of MDR1 gene (in exons 12, 21 and 26) were reported to contribute to the drug resistance in many tumors. The main objectives of this study were to establish the feasible tools for screening of these three most frequent polymorphisms and to investigate the distribution of these polymorphisms in Malay leukemic patients. DNA samples were collected from Malay patients diagnosed as leukemia was subjected to dHPLC and RFLP analyses. From the results, 25 (25.7%) of the patients showed heterozygous mutation, 7 (6.7%) wild type, while 2 (1.9%) showed homozygous mutation. There was a significant difference in the distribution of polymorphisms between exons 21 and 26 (p...
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