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Sulfonamides: X-Ray Structures and Biological Studies


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Год выпуска: 2012
Автор: Waqar Ahmad,Asia Butt and Islam Ullah Khan
Издательство: LAP Lambert Academic Publishing
Страниц: 104
ISBN: 9783659155314
Описание
 The use of antibiotics in the treatment of various infections of humans caused by microbes has been a great success. Over the past years there has been an increase in the resistance of microorganisms against a large number of drugs. Keeping in view the biological activity and medicinal importance of sulfonamides, new sulfonamides are being synthesized. This book describes the synthesis of N-benzyl-4-methylbenzenesulfonamide, its N-alkylated derivatives and evaluation of their anti-microbial activity. N-benzyl-4- methylbenzene sulfonamide was synthesized by the condensation of benzyl amine with p-toluene benzenesulfonylchloride. The solvent used for this reaction was water.N-alkylated derivatives were prepared by reacting N-benzyl-4-methylbenzenesulfonamide with different alkylating agents and sodium hydride using DMF as solvent. The synthesized compounds were characterized by different techniques like X-ray crystallography, FT-IR, Elemental analyzer and melting point. Evaluation of...

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Нина
Здравствуйте Юлия. Защита прошла на "Ура"! Отметка-отлично. Кошмарный сон позади. Спасибо за помощь и сотрудничество!