Год выпуска: 2012 Автор: M. A. Salam and M. A. Affan Издательство: LAP Lambert Academic Publishing Страниц: 112 ISBN: 9783847340836
Описание
Eight new organotin(IV) complexes (3-10) with 2-acetylpyridine-N(4)-cyclohexylthiosemicarbazone [HPACT, (1)] and ten new organotin(IV) complexes (11-20) with 2-benzoylpyridine-N(4)-cyclohexylthiosemicarbazone [HBPCT, (2)] have been synthesized and characterized by various spectroscopic techniques and X-ray crystallography. In all the complexes (3-20), both ligands (1-2) are coordinated to the tin(IV) atom through the thiolato-S, azomethine-N and pyridine-N atoms, respectively. The X-ray study found that the all complexes are monomer and the central tin(IV) atom is six coordinated in a distorted octahedral geometry. The ligands (1-2) and their organotin(IV) complexes (3-20) were screened for their in vitro antibacterial and cytotoxicity. The screening results revealed that all these compounds have shown significant antibacterial and potential antitumor activity. Results of biological studies demonstrate that organotin(IV) derivatives are in general more active than the free ligands. In...