Год выпуска: 2012
Автор: Shuchi Dixit
Издательство: LAP Lambert Academic Publishing
Страниц: 232
ISBN: 9783848443741
Описание Enantioresolution of pharmaceuticals and biologically important compounds continues to be important and challenging task in academia and industry. Sensitive, cost-effective and reproducible methods are reported for chiral separation of such compounds, namely (R,S)-mexiletine, (R,S)-baclofen, ?-blockers (i.e., (R,S)-atenolol, (R,S)-propranolol, (R,S)-bisoprolol, (R,S)-metoprolol and (R,S)-carvedilol), DL-amino acids (both proteinogenic and non-proteinogenic) and certain chiral aldehydes and ketones. Indirect approach of enantioresolution offers several advantages in comparison to direct approach. These include possibility of synthesis of chiral derivatizing reagents (CDRs) that could react easily with the functional group of the analyte, availability of certain CDRs commercially, excellent separation and detection possibilities of the resulting diastereomers, easy optimization of chromatographic conditions, and the prospect of using relatively inexpensive achiral columns. Cyanuric... |
