TOR and GSK3 in the ciliate Paramecium tetraurelia Год выпуска: 2012Автор: Tatyana SvinkinaИздательство: LAP Lambert Academic PublishingСтраниц: 340ISBN: 9783659128356Описание Target of rapamycin (TOR) is a serine threonine kinase that regulates cellular processes in response to the stresses and nutrients in the environment. We investigated TOR signaling pathway in the ciliate Paramecium tetraurelia (P. tetraurelia). Using BLAST (Basic Local Alignment Search Tool) we identified orthologs of the mammalian TOR, LST8, Akt, Rheb, Rag A/B, Rag C/D, SNAT2, Tap42, S6K, PKA and GSK3 in the P. tetraurelia. With RNA interference technique we established that depletion of these orthologs reduced cellular proliferation and arrested cells between G1 and S stages of the cell cycle. Furthermore, GSK3 depletion produced round looking cells with short, sparse cilia, and GSK3 was localized to the pellicle and cilia of P. tetraurelia. In addition to these investigations, we determined that inhibition of PKA with H89 prevented re-growth of cilia in de-ciliated cells. Our results possibly suggest that GSK3 and PKA work together in the regulation of ciliary length and /or...
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Ксюша Здравствуйте Lilik! Сессия закончилась, все сдала без хвостов и без троек, большое спасибо за Вашу работу все просто отлично, как я уже говорила наша преподавательница очень строгая, столько работ завернула, а мне написала рецензию, что ей понравилось, еще раз большое спасибо.
