Год выпуска: 2012 Автор: Talat Roome, PhD Издательство: LAP Lambert Academic Publishing Страниц: 456 ISBN: 9783659204074
Описание
This study is designed to explore anti-inflammatory potential of Aegiceras corniculatum and its mechanism of action against various pro-inflammatory mediators. Rat paw edema and peritonitis model(s) were employed for in vivo studies and for in vitro study human platelets and rat neutrophils were stimulated with Ca+2-ionophore for production of inflammatory metabolites of Cyclooxygenase-I and Lipoxygenases pathways. Methanol extract constituting lignans and saponins caused ~90% reduction in carrageenan and PGE2 -induced paw edema in rats and COX-I metabolites 12-HHT in human platelets. Hexane extract exerts its anti-inflammatory effect on Arachidonic acid metabolites by inhibiting both types of lipoxygenases due to presence of benzoquinones. Ethyl acetate extract has implicated as a dual inhibitor of both COX-I and 5-LOX and this effect attributed to pentacyclic triterpenes and flavonoids. It also ameliorate histamine and serotonin release from mast cells and leukocytes infiltration....
Добрый день! Хочу сказать Марине огромное спасибо за оперативное выполнение заказа - мне необходима была рецензия на дипломную работу. Рецензию я получила уже на следующий день, причем за дешевую цену - всего 500 рублей. Спасибо!