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Immune reconstitution in paediatric patients with HIV-1



Год выпуска: 2014
Автор: Simone Pensieroso
Издательство: LAP Lambert Academic Publishing
Страниц: 132
ISBN: 9783659526527
Описание
Immune system plays a crucial role in defending organism from pathogens. However, immunological functions may be severely impaired by a number of disorders including acquired immunodeficiencies, possibly due to infections, chronic diseases, immunosuppressive drugs or surgeon therapies. Aim of the study was to evaluate immune reconstitution in children with acquired immunodeficiency. Attention was focused on two groups of HIV-1 vertically infected children and on a cohort of leukaemia children who underwent Umbilical Cord Blood Transplantation (UCBT). HIV-infected children showed a significant normalization of immune functions investigated, with a long-term maintaining of good clinical and immunological parameters. Also children who underwent UCBT showed a notable immune restoration. An early application of antiretroviral treatment from the third month of life favours immune reconstitution and the application of a simplified regimen seems to permit the maintenance of good...


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Екатерина, 25.05
Защитилась на хорошо! Спасибо вам большое!!! Комиссия ничего не заметила никаких косяков! =))