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Microgravity- and shear stress- mediated regulation of NEDD4 & Cx43


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Год выпуска: 2013
Автор: Katarzyna Fiedorowicz
Издательство: LAP Lambert Academic Publishing
Страниц: 140
ISBN: 9783659413728
Описание
 The reduction of capillary density in microgravity- induced muscle atrophy has been observed by several studies. Molecular mechanisms leading to this changes remain unknown. Therefore, my studies were designed at testing endothelial reactions on microgravity that are probably connected to the regulation of blood vessel growth. This book presents the results of research on the expression of NEDD4 in endothelial cells, the impact of microgravity and different flow patterns on it, as well as NEDD4 mediated degradation of Cx43 under these conditions. In addition, previous studies revealed that ADAMTS1, which plays a pivotal role in the regulation of angiogenesis, is strongly induced by shear stress. Here, it was also investigated if there is any influence of microgravity on ADAMTS1 expression. These results provide a better understanding of mechanisms which can contribute not only to the development of different pathological situation observed in...

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Здравствуйте, Марина! На днях я защитила диплом после вашего сопровождения на оценку "хорошо". Не без Вашей помощи. :) Спасибо! Желаю успехов в работе!!!