Mouth Dissolving Tablet of Olanzapine by Solid Dispersion Technique Год выпуска: 2012Автор: Vishal Brahmbhatt,Natvarlal Patel and Mukesh PatelИздательство: LAP Lambert Academic PublishingСтраниц: 136ISBN: 9783659133084Описание In the present investigation, solid dispersion of olanzapine has been prepared to improve its solubility. Further, using solid dispersion, mouth dissolving tablet was prepared to overcome the problem of swallowing. A Simplex Lattice design was applied using three factors, i.e. superdisintegrants like croscarmellose sodium(X1) crospovidone(X2), and sodium starch glycolate(X3) in tablet formulation. Disintegration time, Wetting time, Water absorption, T50 (Time required to 50% drug release) and Q10 (percentage of drug released in 10 min.) taken as responses. Solid dispersion showed significant enhancement in solubility of olanzapine. For mouth dissolving tablet, batch containing 5% croscarmellose sodium alone had minimum disintegration time (44 sec.) and faster drug release(T50: 40 sec) compared to other batches.
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Scorpion Извиняюсь, что так и не ответил и не поблагодарил. Куча работы, суматоха, до компьютера не добраться. Делаю это сейчас. Большое спасибо за сопровождаемую работу и консультации. Вы мне очень помогли. Теперь буду заниматься редакциями и дополнениями. Получилось так, что в связи с последним экзаменом и сроками сдачи его, защита работы откладывается на конец этого года. Теперь все предметы позади, главное подготовиться к защитите. Еще раз благодарю и говорю спасибо за помощь в проделанной работе.
