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Formulation Of Fast Dissolving Tablets Of Phenylephrine Hydrochloride


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Год выпуска: 2013
Автор: Nikunj Chapla,Vishal Chapla and Naisarg Pujara
Издательство: LAP Lambert Academic Publishing
Страниц: 148
ISBN: 9783659346040
Описание
 Recent advances in novel drug delivery system aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach is fast dissolving tablets (FDT) of Phenylephrine Hydrochloride, a selective ?1 adrenergic receptor antagonist, used for nasal decongestant and producing mydriasis effect. In present work an attempt has been made by formulating fast dissolving tablets of Phenylephrine Hydrochloride by superdisintegrants addition method using croscarmellose sodium, crospovidone and sodium starch glycolate. A total of 10 batches were prepared by using various combination and concentration of superdisintegrants and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release studies, kinetic studies and stability studies. Amongst all the formulations F2 and F9 were found to be better formulations which include...

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Мария, здравствуйте, спасибо огромное, что не подвели меня! Сейчас сижу, читаю вашу работу. Мне нравится