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Synthetic methods, chemistry and anticonvulsant screening of indoles



Год выпуска: 2013
Автор: Md Shamsher Alam and Nadeem Siddiqui
Издательство: LAP Lambert Academic Publishing
Страниц: 164
ISBN: 9783659372551
Описание
Clinically available drugs (95%) for epilepsy treatment were approved before 1985 and they could provide satisfactory seizure control for 60-70% of the patients. These drugs however also cause notable adverse side effects and have life-threatening conditions. Thus, there is constant need for compounds with improved neuropharmacological activities with lower toxicities. Research to find more effective and safer antiepileptic drugs are therefore imperative and challenging in medicinal chemistry. Indole and its derivatives are used in organic synthesis and they are used in evaluating new product that possess different biological activities. Several newer benzfused five membered heterocyclic derivatives based on the pharmacophore models are intended to be synthesized which are expected to possess better anticonvulsant activity with lower neurotoxicity. It is hoped that this book will have wide appeal for undergraduates, postgraduates, and practitioners in the health sciences (e.g.,...


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Дима, 27.09
Здравствуйте. Марина Михайловна огромное вам спасибо, я защитил на хорошо, только они мой доклад даже слушать не стали сразу попросили назвать Цели и задачи и начали вопросы задавать, но я справился. Спасибо огромное!!!!!!!!!!!!