Год выпуска: 2012 Автор: Shashidher Burra and Veera Reddy Prabakhar Reddy Издательство: LAP Lambert Academic Publishing Страниц: 80 ISBN: 9783659183140
Описание
The present study enlightens to enhance the dissolution profile, absorption efficiency and bioavailability of water insoluble drugs like carvedilol. A novel “Powder Solution Technology” involves absorption and adsorption efficiency, which makes use of liquid medications admixed with suitable carriers and coating materials and formulated into a free flowing, dry looking, non adherent and compressible powder forms. Based upon a new mathematical model expression improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of carrier and coating material ratio from 20:1 to 5:1. Di calcium phosphate , Avicel ® PH 200 were showing acceptable flow properties compared with Avicel ®PH 101 and Lactose. Higher dissolution rates (98.4%) were observed in Poly ethylene glycol 400 and Avicel ®PH 200 containing liquisolid formulations (F5) compared with marketed product (CARCA® 12.5 mg tablets) 81% drug release. Poly ethylene glycol 400 was...