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Interaction of Palmitic Acid with Metoprolol Succinate



Год выпуска: 2012
Автор: Mohammad Firoz Khan,Jayanta Kishor chakrabarty and Mashiur Rahman
Издательство: LAP Lambert Academic Publishing
Страниц: 96
ISBN: 9783659269547
Описание
The binding of Metoprolol succinate, a ?-adrenoceptor blocker, to bovine serum albumin was studied by equilibrium dialysis method at 28?C and pH 7.4. The study was carried out by using ranitidine and diazepam as site-I and site-II specific probe, respectively. Since, dietary fatty acids are highly protein bound, hence the binding profiles of metoprolol succinate were also characterized in presence or absence of Palmitic acid. The interactions of dietary fatty acids and other endogenous ligands are supposed to interfere the pharmacokinetics and protein binding profiles of the drugs. Therefore, the present study was undertaken to investigate the inside binding profiles of metoprolol sucinate and displacement of metoprolol sucinate from binding sites in presence of endogenous ligands or dietary components. This research provided the evidence of interaction of higher concentration of palmitic acid at the binding sites on BSA changing the pharmacokinetics properties of Metoprolol...


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Ольга
Здравствуйте сегодня была защита диссертации. Защитила на отлично. Большое спасибо за своевременную качественно проделанную работу.