Год выпуска: 2012
Автор: Hafiz Awais Nawaz,Muhammad Irfan Masood and Mateen Abbas
Издательство: LAP Lambert Academic Publishing
Страниц: 116
ISBN: 9783659238437
Описание This study was designed to compare the pharmacokinetic parameters of Candesartan in healthy male & female volunteers. The male volunteers were considered as group A and female volunteers as group B. Both groups were administered Candesartan 16mg tablet orally. 5ml Blood samples were collected at 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 6, 8, 12, 24, 48 & 72 hr after the drug administration. Plasma was separated by centrifugation at 5000 RPM and stored at -80?C till analysis. Candesartan concentrations in plasma were measured by HPLC method. All pharmacokinetic parameters were calculated through software APO pharmacological analysis MW/PHARM version 3.02 by assuming bio-availability of Candesartan after oral administration as 1. Pharmacokinetic parameters of Candesartan were compared in both groups. Data was analyzed by unpaired t-test and it was observed that there is significant difference in AUC of Candesartan in male and female volunteers without any effect in Cmax, Tmax, Vd, Ka or t1/2.... |
