Год выпуска: 2012 Автор: Ishtiaq Ahmed and Shahana Sharmin Издательство: LAP Lambert Academic Publishing Страниц: 148 ISBN: 9783846595169
Описание
This book is related to a study involving development and in vitro evaluation of sustained release pellets of ambroxol hydrochloride prepared by extrusion spheronization followed by fluid bed coating with the commercial aqueous polyvinyl acetate dispersion (Kollicoat SR 30 D); aqueous dispersion of ethyl acrylate and methyl methacrylate (Eudragit NE 30 D) and aqueous dispersion of acrylic and methacrylic acid esters (Eudragit RL 30 D and Eudragit RS 30 D). The release of ambroxol hydrochloride from coated pellets was investigated at different coating level. The release mechanism was explored and explained with zero order, first order, Higuchi equation and Korsmeyer’s equation. The Mean Dissolution Time (MDT) value was calculated for all the formulations to determine the release retarding ability of the polymers. The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer load and physico-chemical nature of the drug....
Здравствуйте, Юлия. Спешу сообщить Вам что защита Курсовой состоялась успешно, немного я там, правда, намудрила, но в итоге результат 4(хорошо). Огромное Вам спасибо. Надеюсь на дальнейшее сотрудничество.