Год выпуска: 2014 Автор: Subhadip Banerjee,Pratip Kumar Debnath and Anil Kumar Saikia Издательство: LAP Lambert Academic Publishing Страниц: 148 ISBN: 9783659511172
Описание
Ayurveda the science of life presents invaluable source of ethnopharmacological resources. This traditional knowledge inspires novel drug discovery from natural products. Reverse pharmacology taking a Bedside to Bench approach can be a rational approach in that direction.The book presents the development of herbal anti-tubercular adjunct therapy from the Vedic plant Aswagandha (Withania somnifera).The study details description of Aswagandha as a drug with poly-pharmacological effect and various other important facts including cultivation, phytochemistry to chemical biology.Then the initial herbo-epidemological study done in clinical set-up has been enumerated.Finally the Bedside to Bench study where the clinical study was validated and studied at the molecular level using chromatography and in-silico studies.A novel mechanism of action behind the observed anti-tubercular effect was observed where phytomolecules from the plant has been found to interact with the target.This...
