Год выпуска: 2013 Автор: Manzoor Ahmad Mir,Raid S. Albaradie and Javed N. Agrewala Издательство: LAP Lambert Academic Publishing Страниц: 168 ISBN: 9783659390678
Описание
Cancer is a major health problem worldwide and is one of the most prominent causes of morbidity and mortality in children and adults causing about 9 million deaths annually. The success of novel cancer therapies depends on the identification of functional targets that play an essential role in tumor growth and metastasis, survival and evasion from immunosurveillance. Costimulation through CD80 or through CD28-bearing T cells, regresses the growth in B cell lymphomas retard the proliferation and induce apoptosis. On the other hand Tuberculosis(MTB) a major infectious disease is becoming global emergency due to BCG failure and multidrug resistance and hence needs urgent attention from scientific community to develop alternative strategies to defeat the problems linked to the reemergence of TB. Macrophages activated through anti-B7-1 and anti-B7-2 mAbs showed enhanced microbicidal function and reduced the survival of MTB. Therefore this novel strategy can be effectively exploited to...
