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Formulation And Evaluation Of Cinnarizine Floating Tablets



Год выпуска: 2012
Автор: Sumit Doshi and Uma Patil
Издательство: LAP Lambert Academic Publishing
Страниц: 144
ISBN: 9783659240973
Описание
Cinnarizine, a piperazine derivative with anti-histaminic activity finds its major use in control of vomiting due to motion sickness. It has a short half-life of 3-6 hrs. & the usual dosage regimen is 75 mg twice or three times a day for adults. The floating tablets of cinnarizine were formulated using varying concentration of HPMC K4M & effervescent agents by wet granulation technique. The granules were evaluated for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio & drug content. The tablets were evaluated for thickness, hardness, weight variation test, friability, in vitro buoyancy & in vitro dissolution study. A 3 Square factorial design was used to study the effect of HPMC K4M & citric acid on lag time, floating time & percentage cumulative release. The responses were analyzed using ANOVA & by the predictive equation, it was found that the concentration of HPMC K4M & citric acid significantly affected all the response parameters. The obtained model was...


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Отзывы
Наташа, 09.03
Юлия здравствуйте я заказывала у вас работу :, извините что так поздно пишу, за работу получила одна из группы 5, у нашего профессора, хотелось сказать вам большое спасибо!