Development of Mucoadhesive Buccal Patches of Flurbiprofen Год выпуска: 2011Автор: santosh mishra,Sobhna Singh and Ranjit SinghИздательство: LAP Lambert Academic PublishingСтраниц: 140ISBN: 9783844310559Описание In the present study, an attempt was made to formulate mucoadhesive buccal patches of flurbiprofen (FBN) in order to enhance solubility. Solubity enhancement was attempted by making solid dispersion of drug with ?-CD (cyclodextrin). Initially preformulation were carried out using reported methods. Buccal patches was prepared by solvent casting technique using polymers like Polyvinyl alcohol (PVA), Sodium carboxymethylcellulose (SCMC),and Hydroxypropyl methyl cellulose (HPMC). The prepared patches were evaluated for their weight variation, thickness, folding endurance, surface pH, swelling index, in-vitro residence time, in-vitro permeation studies, drug content uniformity and bioadhesion test.
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Ирина, 09.10 Огромное спасибо за помощь! Без вас бы не справилась! Сорри, что сразу не отписала, просто на основной работе был аврал! Сегодня первый день передыха! :)) Спасибо еще раз!
