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Formulation and Evaluation of Delayed Release Tablet


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Год выпуска: 2013
Автор: Tushar Rukari
Издательство: LAP Lambert Academic Publishing
Страниц: 64
ISBN: 9783659356896
Описание
 In the present work emphasize on Esomeprazole magnesium is formulated as delayed release tablets to provide desired effect at certain time in maintained drug concentration without any unwanted effect with patient compliance also to improve it bioavailability by decreasing its expose to gastric acid. A delayed release dosage form is designed to release the drug from the dosage form at a time other than promptly after administration. UV spectrophotometric method has been developed for the estimation of Esomeprazole in pharmaceutical formulations. Then the tablets were prepared by wet granulation method rather than direct compression because of cohesive property of the drug. Optimized core tablet then subjected for enteric coating by selected base coat polymer cellulose derivative for preventing core tablet from moisture. The coated formulations were compared with marketed sample (ESOZ) for optimization. Dissolution results of tablets with enteric coating have shown release of...

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