Год выпуска: 2012 Автор: Md. Kaosar Niaz Bin Sufian,Hiroshi Hara and Tohru Hira Издательство: LAP Lambert Academic Publishing Страниц: 132 ISBN: 9783659307799
Описание
The release of so called anti-diabetic, anti-obesity gut hormone cholecystokinin (CCK) from I-cells of the small intestine is stimulated by some food peptides, which in turn suppresses appetite by producing a feeling of satiety. This study investigated appetite-suppressive and CCK-releasing activity in peptides derived from proteins after enzymatic hydrolysis. The stimulatory activity was examined in a murine enteroendocrine cell (EEC) line STC-1 followed by investigating active peptides for appetite-suppression in rats. Among peptones prepared from meat and legumes, pork peptides suppressed appetite correspondingly with binding to rat small intestinal brush-border membrane and by stimulating CCK secretion from the EECs. Peptides in country bean (Dolichos lablab) had the highest stimulation in CCK-secretion. The active peptides are originated from ‘dolicholin’–a newly identified protein in country bean. Despite low peptide content, brewer’s yeast extract with ~14 kDa peptides showed...